Lipid-Protein Interactions are Unique Fingerprints for Membrane Proteins
نویسندگان
چکیده
منابع مشابه
Specific protein-lipid interactions in membrane proteins.
Many membrane proteins selectively bind defined lipid species. This specificity has an impact on correct insertion, folding, structural integrity and full functionality of the protein. How are these different tasks achieved? Recent advances in structural research of membrane proteins provide new information about specific protein-lipid interactions. Tightly bound lipids in membrane protein stru...
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Studies of lipid-protein interactions in double-reconstituted systems involving both integral and peripheral or lipid-anchored proteins are reviewed. Membranes of dimyristoyl phosphatidylglycerol containing either myelin proteolipid protein or cytochrome c oxidase were studied. The partner peripheral proteins bound to these membranes were myelin basic protein or cytochrome c, respectively. In a...
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In each case the complexes were suspended in 20rn~-Tris/HCl (pH 8.0)/0.1% LDAO (v/v). The circles indicate where the recording spectrophotometer stopped and the spectra were continued point by point in another machine. (a) Complexes from strain 7750 grown at 2000k: 0, type 1 B800-850; 0, RC-B880. (b) Complexes from strain 7050 grown at 4001~: 0, type 2 B800-850; this spectrum was raised to make...
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The recognition of protein interaction sites is an important intermediate step toward identification of functionally relevant residues and understanding protein function, facilitating experimental efforts in that regard. Toward that goal, the authors propose a novel representation for the recognition of protein-protein interaction sites that integrates enhanced relative solvent accessibility (R...
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The interactions between membrane proteins and their lipid bilayer environment play important roles in the stability and function of such proteins. Extended (15-20 ns) molecular dynamics simulations have been used to explore the interactions of two membrane proteins with phosphatidylcholine bilayers. One protein (KcsA) is an alpha-helix bundle and embedded in a palmitoyl oleoyl phosphatidylchol...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.500